Deliverables
Deliverables
Restricted access to deliverables
Some of the deliverables listed below contain sensitive information and are not publicly available.
D1.4 – Summary Report WP1
This deliverable provides a summary of the work performed in WP1 – Bio-inks Formulation, Characterization & Testing.
WP1 successfully developed hyaluronic acid-based bioactive inks with tunable drug release and enzyme-responsive degradation. The systems exhibit key features required for multifunctional wound dressings, including pH sensitivity, controlled drug release, and biodegradability under wound-relevant conditions. Although the analytical quantification of antibiotics remains challenging, the overall performance of the three bioactive inks is promising. WP1 has established a strong scientific and technological foundation for the development of advanced, stimulus-responsive wound dressings within the FORCE REPAIR project.
D3.7 – Summary Report WP3
This deliverable provides a summary of the work performed in WP3 – Selection via In Vitro and Ex Vivo Testing.
WP3 provided a comprehensive evaluation of the developed bioinks and hydrogel-based scaffolds, focusing on their antibacterial activity, regenerative capacity, biocompatibility, immune safety, bioadhesion, and performance under clinically relevant conditions. The combined mupirocin–tobramycin formulations demonstrated broad-spectrum antibacterial efficacy, including activity against complex biofilms, while remaining compatible with human cells.
Advanced in vitro models confirmed the neuro-supportive potential of the bioinks by promoting neurite outgrowth, although angiogenic responses were limited under the tested conditions. All hydrogel formulations were non-cytotoxic, supported cell recruitment, and enabled efficient cellular uptake of nanocapsules, confirming their suitability as delivery systems. Immunological analyses demonstrated a favourable safety profile, with no non-specific immune activation and preserved immune cell viability, even during bacterial challenge. The hydrogels also showed strong and tunable bioadhesive properties, particularly in the pro-regenerative formulations, supporting stable interaction with biological tissues. Finally, tests using human wound exudates showed that the bioinks could restore fibroblast proliferation under pathological conditions, although their immunomodulatory effects varied depending on the inflammatory microenvironment.